کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1396042 | 1501170 | 2011 | 7 صفحه PDF | دانلود رایگان |

1,4-Naphthoquinones are unique reagents in organic synthesis and have been employed in several well known and recently developed areas of application. Furthermore, these 1,4-naphthoquinones have demonstrated high reactivity in nucleophilic vinylic substitutions, in the preparation of sulfurated, (hetero)cyclic and several other transformations. This study describes the synthesis and biological evaluation of derivatives of monosulfurated naphthalene-1,4-dione (3), 3-chloro-2-ethoxy-naphthalene-1,4-dione (4), disulfurated naphthalene-1,4-dione (5), and symmetrical bis-1,4-naphthoquinones (7, 9) were obtained from the reaction of 2,3-dichloro-naphthaquinone (1) with S-, O-substituted mono-, di-, and tetrathiols, respectively. The structures of the novel products were characterized by spectroscopic methods.
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► A convenient synthesis route of novel thio-substituted naphthalene-1,4-diones has been reported.
► Biological activities evaluated at low MIC against bacteria and fungi.
► (3a), (4c), (5d), and (5f) are promising as biologically active compounds.
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 12, December 2011, Pages 5861–5867