کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1396237 | 1501183 | 2010 | 6 صفحه PDF | دانلود رایگان |
Several novel molecules, 1-(3′-(9H-carbazol-4-yloxy)-2′-hydroxypropyl)-3-aryl-1H-pyrazole-5-carboxylic acid derivatives 3a–g were synthesized and screened to evaluate their cytotoxicity against cancer cells in vitro. The compounds 3a–g has been prepared by the reaction of ethyl 3-aryl-1H-pyrazole-5-carboxylate with 4-oxiranylmethoxy-9H-carbazole in moderate to excellent yields. The cytotoxicity of synthesized compounds was evaluated by a SRB (sulforhodamine B) assay against cancer cell such as SK–N–SH human neuroblastoma (NB), human A549 lung carcinoma, human breast cancer MCF-7 cell lines. The results showed that seven compounds can suppress SK–N–SH tumor cancer cell growth. Among them, compound 3d was the most effective small molecule in inhibiting SK–N–SH cell growth.
Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 11, November 2010, Pages 4720–4725