کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1396309 1501183 2010 6 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
A convenient synthesis of 13N-labelled azo compounds: A new route for the preparation of amyloid imaging PET probes
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موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A convenient synthesis of 13N-labelled azo compounds: A new route for the preparation of amyloid imaging PET probes
چکیده انگلیسی

In the present paper, a fast and automated method for the synthesis of 13N-labelled azo compounds is reported for the first time. The labelling strategy is based on trapping [13N]NO2− in an anion exchange resin. The reaction with primary aromatic amines in acidic media led to the formation of the corresponding diazonium salts, which were further reacted with aromatic amines and alcohols to yield the corresponding 13N-labelled azo derivatives with good radiochemical conversion (40.0–58.3%). Good radiochemical yields (20.4–47.2%, decay corrected) and radiochemical purities (>99.9%) were obtained after purification by HPLC. Such methodology can be easily applied to the preparation of a wide range of 13N-labelled azo derivatives by adequate selection of the non-radioactive precursors.

The synthesis of 13N-diazonium salts has been achieved by reaction of [13N]NO2− with primary aromatic amines in acidic media. Further reaction with aromatic amines and phenols yielded the corresponding 13N-labelled azo compounds, which might have putative application as PET imaging probes for the in vivo detection of amyloid deposits.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 11, November 2010, Pages 5318–5323
نویسندگان
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