کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1397157 | 1501235 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and evaluation of cytotoxic activity of arylfurans
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
A series of 2-aryl and 2,5-diarylfurans were synthesized and evaluated for their in vitro cytotoxicity against human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA). Three compounds were found to present significant activity against the cancer cell lines without affecting the lymphocyte proliferation in PBMCs, indicating low toxicity to normal cells.
A series of 2- and 2,5-arylfurans were synthesized and evaluated for their in vitro toxicity to human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA).Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 6, June 2006, Pages 756–760
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 6, June 2006, Pages 756–760
نویسندگان
Renata B. de Oliveira, Elaine M. de Souza-Fagundes, Helen A.J. Siqueira, Rodrigo S. Leite, Claudio L. Donnici, Carlos L. Zani,