کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1397697 | 1501188 | 2010 | 15 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis, biological evaluation and molecular docking of novel series of spiro [(2H,3H) quinazoline-2,1′- cyclohexan]-4(1H)- one derivatives as anti-inflammatory and analgesic agents Synthesis, biological evaluation and molecular docking of novel series of spiro [(2H,3H) quinazoline-2,1′- cyclohexan]-4(1H)- one derivatives as anti-inflammatory and analgesic agents](/preview/png/1397697.png)
Three series of Spiro [(2H,3H) quinazoline-2,1′-cyclohexan]-4(1H)-one derivatives have been synthesized. Some of the novel quinazolinone derivatives IIe, VIIIc, XIc, XIIb, XIIc, XVIb showed considerable potent anti-inflammatory and analgesic activity of superior G.I.T. safety profile in experimental rats in comparing to indomethacin and tramadol as reference drugs. Docking study into COX-2 has been made for derivatives of highest anti-inflammatory activity. The compound XVIb showed the nearest RMSD value to that of indomethacin.
Three series of Spiro [(2H, 3H) quinazoline-2,1′-cyclohexan]-4(1H)-one derivatives have been synthesized. Some of the derivatives were evaluated as anti-inflammatory and analgesic agents using indomethacin and tramadol as reference drugs. The biological data were compared to the molecular docking study.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 6, June 2010, Pages 2117–2131