A novel series of cytotoxic iridoid glucosides derived from aucubin: Design, synthesis and structure–activity relationships

Five new unsaturated iridolactones 3–7 related to natural cytotoxic oxylipins, Tei 9826, and iridolactone 2, were prepared by parallel synthesis from natural aucubin. It was found that perpivaloyl iridoid glucosides 2, 3, and 4 were markedly cytotoxic against both L1210 and KB-3-1 cell lines.

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