کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1397882 1501194 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity
چکیده انگلیسی

There is increasing demand for novel anti-inflammatory drugs with different mechanisms of action. We synthesized a series of isothiocyanates 2b–h based on 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) found in the pungent spice Wasabia japonica. Inhibitory activities against in-vitro growth of tumor cells and production of nitric oxide (NO) using the mouse macrophage-like cell line J774.1 were noted. All isothiocyanates were optimized by Hartree-Fock/3-21G model, and the log P values and the polar surface area (PSA) values were calculated. Substitution of the methylsulfinyl group (CH3S(O)–R) in 6-MITC with a formyl (CHO–R), a methylsulfanyl (CH2S–R) or a methyl (CH3–R) group reduced the activities of the parent isothiocyanate. Substitution with a formyl group resulted in lower lipophilicity (log P value) whereas substitution with a methylsulfanyl or methyl group resulted in a lower PSA value. The inhibitory activity of isothiocyanates showed better correlation with their PSA values rather than their partition coefficient (log P) values. Isothiocyanates with higher PSA values and some degree of log P value may have potent biological activity.

A novel series of isothiocyanates were synthesized, and evaluated for anti-nitric oxide (NO) production activities. The inhibitory activity of isothiocyanates showed a good correlation with their PSA values.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 12, December 2009, Pages 4931–4936
نویسندگان
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