کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1399990 1501231 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and anticonvulsant activity of some potential thiazolidinonyl 2-oxo/thiobarbituric acids
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and anticonvulsant activity of some potential thiazolidinonyl 2-oxo/thiobarbituric acids
چکیده انگلیسی

A series of 5-[(N-substituted benzylidenylimino)amino]-2-oxo/thiobarbituric acids (3a–3h) have been synthesized by the condensation of 5-hydrazino-2-oxo/thiobarbituric acids (2a–2b) with various aromatic aldehydes. Cycloaddition of thioglycolic acid to 3a–3h, yielded 5-[(2′-substituted phenyl-4′-oxothiazolidin-3′-yl)amino]-2-oxo/thiobarbituric acids (4a–4h). All these compounds were screened, in vivo, for their anticonvulsant activity and acute toxicity studies. Compounds 4f and 4g were found to be most potent compounds of this series and were compared with the reference drugs, phenytoin sodium, lamotrigine and sodium valproate. The structures of these compounds have been established by IR, 1H NMR and mass spectroscopic data.

A novel series of oxo/thiobarbituric acids derivatives have been synthesized and evaluated for potential anticonvulsant activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 10, October 2006, Pages 1223–1229
نویسندگان
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