کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399990 | 1501231 | 2006 | 7 صفحه PDF | دانلود رایگان |

A series of 5-[(N-substituted benzylidenylimino)amino]-2-oxo/thiobarbituric acids (3a–3h) have been synthesized by the condensation of 5-hydrazino-2-oxo/thiobarbituric acids (2a–2b) with various aromatic aldehydes. Cycloaddition of thioglycolic acid to 3a–3h, yielded 5-[(2′-substituted phenyl-4′-oxothiazolidin-3′-yl)amino]-2-oxo/thiobarbituric acids (4a–4h). All these compounds were screened, in vivo, for their anticonvulsant activity and acute toxicity studies. Compounds 4f and 4g were found to be most potent compounds of this series and were compared with the reference drugs, phenytoin sodium, lamotrigine and sodium valproate. The structures of these compounds have been established by IR, 1H NMR and mass spectroscopic data.
A novel series of oxo/thiobarbituric acids derivatives have been synthesized and evaluated for potential anticonvulsant activity.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 10, October 2006, Pages 1223–1229