Ibuprofen analysis in blood samples by palladium particles-impregnated sodium montmorillonite electrodes: Validation using high performance liquid chromatography

• Impregnation of palladium onto sodium montmorillonite (Pd-PdO/MMT).
• Oxidation of ibuprofen using Pd-PdO/MMT modified carbon electrode.
• Optimization of electrochemical and chemical variables in detecting ibuprofen.
• Ibuprofen analysis in blood samples.

The electrochemical detection of ibuprofen has been studied on Palladium-Montmorillonite (Mt) modified carbon paste electrode using differential pulse voltammetry. The optimization of the modifier preparation and the instrumental parameters was investigated. The results indicate that ibuprofen oxidation was favored in the presence of Pd–PdO particles. The quantitative determination of ibuprofen was statistically analyzed and validated using HPLC method. The detection and quantification limits, specificity and precision were found to be acceptable. Finally, the developed method was successfully applied for ibuprofen determination in human blood samples.

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