کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1428180 1509172 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of CNT on collagen fiber structure, stiffness assembly kinetics and stem cell differentiation
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Effect of CNT on collagen fiber structure, stiffness assembly kinetics and stem cell differentiation
چکیده انگلیسی


• The effect of CNT on collagen fiber structure, stiffness and assembly was examined.
• The changes were attributed to increased local ionic strength and CNT rigidity.
• The molecular interaction between collagen and CNT induced the D-period elongation.
• COL–CNT matrix provides unique cues to promote neural differentiation.

Collagen is a native one-dimensional nanomaterial. Carbon nanotube (CNT) was found to interface with biological materials and show promising applications in creating reinforced scaffolds for tissue engineering and regenerative medicine. In this study, we examined the unique role of CNT in collagen fiber structure, mechanical strength and assembly kinetics. The results imply that CNT interacts with collagen at the molecular level. It relaxes the helical coil of collagen fibrils and has the effect of flattening the fibers leading to the elongation of D-period, the characteristic banding feature of collagen fibers. The surface charge of oxidized CNT leads to enhanced local ionic strength during collagen fibrillogenesis, accounting for the slower kinetics of collagen–CNT (COL–CNT) fiber assembly and the formation of thicker fibers. Due to the rigidity of CNT, the addition of CNT increases the fiber stiffness significantly. When applied as a matrix for human decidua parietalis placental stem cells (hdpPSCs) differentiation, COL–CNT was found to support fast and efficient neural differentiation ascribed to the elongated D-period. These results highlight the superiority of CNT to modulate collagen fiber assembly at the molecular level. The study also exemplifies the use of CNT to enhance the functionality of collagen for biological and biomedical applications.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 49, 1 April 2015, Pages 281–289
نویسندگان
, , , , ,