کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1428198 1509172 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite
چکیده انگلیسی


• Polycaprolactone-bioactive glass (PCL-BG) was coated on the Mg scaffolds.
• Degradation resistance of Mg scaffold was enhanced using PCL-BG coating.
• Bioactivity of Mg scaffolds was increased using PCL-BG coating.
• Mechanical stability of Mg scaffolds was improved using PCL-BG coating.

A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dip-coating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold. Moreover, the mechanical integrity of the Mg scaffolds was improved using the PCL-BG coating on the surface. The stable barrier property of the coatings effectively delayed the degradation activity of Mg scaffold substrates. Moreover, the coatings induced the formation of apatite layer on their surface after immersion in the SBF, which can enhance the biological bone in-growth and block the microcracks and pore channels in the coatings, thus prolonging their protective effect. Furthermore, it was shown that a three times increase in the concentration of PCL-BG noticeably improved the characteristics of scaffolds including their degradation resistance and mechanical stability. Since bioactivity, degradation resistance and mechanical integrity of a bone substitute are the key factors for repairing and healing fractured bones, we suggest that PCL-BG is a suitable coating material for surface modification of Mg scaffolds.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 49, 1 April 2015, Pages 436–444
نویسندگان
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