کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1428386 1509174 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TiO2/PCL hybrid materials synthesized via sol–gel technique for biomedical applications
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
TiO2/PCL hybrid materials synthesized via sol–gel technique for biomedical applications
چکیده انگلیسی


• TiO2/PCL hybrids were obtained by the sol–gel process for biomedical applications.
• Synthesized materials were found to be first-class hybrid nanocomposites.
• Hybrids appear to be bioactive, a fundamental characteristic for osseointegration.
• MTT and Trypan Blue viability test show that the materials are biocompatible.
• The organic phase is able to modulate the biocompatibility of the materials.

The aim of the present work has been the synthesis of organic/inorganic hybrid materials based on titanium dioxide and poly(ε-caprolactone) (PCL) to be used in the biomedical field. Several materials have been synthesized using sol–gel methods by adding different amounts of polymer to the inorganic sol. The obtained gels have been characterized using Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM) and atomic force microscopy (AFM). The FT-IR data allowed us to hypothesize that the structure formed was that of an interpenetrating network, realized by hydrogen bonds between TiOH groups in the sol–gel intermediate species and carbonyl groups in the polymer repeating units. SEM and AFM analyses highlighted that the obtained materials were nanostructurated hybrids. To evaluate the biological properties of the hybrids, their bioactivity and cytotoxicity were investigated as a function of the PCL amount. The bioactivity of the synthesized systems was proven by the formation of a hydroxyapatite layer on the surface of samples soaked in a fluid simulating human blood plasma (SBF). MTT cytotoxicity tests and Trypan Blue dye exclusion tests were carried out exposing NIH-3T3 mouse embryonic fibroblasts for 24 and 48 h to extracts from the investigated hybrid materials. The results showed that all the hybrids had a non-cytotoxic effect on target cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 47, 1 February 2015, Pages 135–141
نویسندگان
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