Facile synthesis of nano silver ferrite (AgFeO2) modified with chitosan applied for biothiol separation

• Facile synthesis of AgFeO2 and AgFeO2@chitosan has been reported
• Surface modification of AgFeO2 with chitosan was presented
• Applications for biothiols were investigated using mass spectrometry
• Novel application as surface for SALDI-MS were successfully reported

Silver iron oxide nanoparticles (AgFeO2 NPs) with narrow size distribution have been synthesized, characterized and was applied for biothiols separation. AgFeO2 and AgFeO2 modified chitosan (AgFeO2@CTS NPs) were synthesized using a hydrothermal method and then characterized by electron microscopy (transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX)), X-ray diffraction (XRD), and Fourier transform infrared (FTIR). Different biological thiols (dithiothreitol, glutathione, thiabendazole, and sulfamethizole) were investigated and characterized using matrix assisted laser desorption/ionization mass spectrometry (MALDI–MS) and surface assisted laser desorption/ionization mass spectrometry (SALDI–MS). The new material displays dual functionality; 1) for separation and 2) can be served as the matrices for SALDI–MS. Data showed a clear background in the case of nanomaterials compared to conventional matrices (mefenamic acid and 2,5-dihydroxybenzoic acid (DHB) for MALDI–MS).

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