کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1428625 1509179 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The influence of low concentrations of a water soluble poragen on the material properties, antibiotic release, and biofilm inhibition of an acrylic bone cement
ترجمه فارسی عنوان
تأثیر غلظت های پایین پراگن محلول در آب بر خواص مواد، انتشار آنتی بیوتیک و مهار بیوفیلم یک سیمان اکریلیک استخوان
کلمات کلیدی
سیمان استخوانی عفونت، انتشار مواد مخدر، ویژگی های مکانیکی، بیوفیلم
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


• Xylitol was incorporated into an acrylic bone cement containing gentamicin.
• Mechanical, drug elution, thermal and biofilm inhibition properties were measured.
• Mechanical properties were significantly influenced by xylitol content.
• Antibiotic release was substantially enhanced over a 45 day period.
• Xylitol did not reduce biofilm formation.

Soluble particulate fillers can be incorporated into antibiotic-loaded acrylic bone cement in an effort to enhance antibiotic elution. Xylitol is a material that shows potential for use as a filler due to its high solubility and potential to inhibit biofilm formation. The objective of this work, therefore, was to investigate the usage of low concentrations of xylitol in a gentamicin-loaded cement. Five different cements were prepared with various xylitol loadings (0, 1, 2.5, 5 or 10 g) per cement unit, and the resulting impact on the mechanical properties, cumulative antibiotic release, biofilm inhibition, and thermal characteristics were quantified. Xylitol significantly increased cement porosity and a sustained increase in gentamicin elution was observed in all samples containing xylitol with a maximum cumulative release of 41.3%. Xylitol had no significant inhibitory effect on biofilm formation. All measured mechanical properties tended to decrease with increasing xylitol concentration; however, these effects were not always significant. Polymerization characteristics were consistent among all groups with no significant differences found. The results from this study indicate that xylitol-modified bone cement may not be appropriate for implant fixation but could be used in instances where sustained, increased antibiotic elution is warranted, such as in cement spacers or beads.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 42, 1 September 2014, Pages 168–176
نویسندگان
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