Morphological structure and characteristics of hydroxyapatite/β-cyclodextrin composite nanoparticles synthesized at different conditions

Hydroxyapatite (HA) nanoparticles were prepared simply in the presence of β-cyclodextrin (β-CD). Mixing sequence of ion precursors during the synthesis of HA greatly affected the morphological structure of nanoparticles. Ca–P showed only the sphere-like structure, however P–Ca exhibited the mixture of spherical and rod-like nanoparticles. The size of nanoparticles slightly decreased with increasing the content of β-CD. The HAs synthesized in the presence of β-CD agglomerated, leading to the formation of aggregates with a size of hundreds nanometer and narrow size distribution. FT-IR, XRD and XRF analyses confirmed that the HA nanoparticles could be synthesized with using β-CD, in which the Ca/P molar ratio was ranged from 1.72 to 1.70. The crystalline phase of these HA nanoparticles was similar to that of the stoichiometric HA. In addition, the content of β-CD contained in the products could influence the initial deposition rate of bone-like apatite on the surface of HA nanoparticles in simulated body fluid (SBF).

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► HA nanoparticles were simply synthesized with using β-CD as template.
► Ca/P molar ratio of HAs was in the range of 1.70‒1.72.
► Formation of aggregates with a size of hundreds nanometer was observed.
► Synthesis procedure affected the morphological structure of HA nanoparticles.
► β-CD content influenced the initial deposition rate of bone-like apatite on HAs.