Influence of water content on hardening and handling of a premixed calcium phosphate cement

Handling of calcium phosphate cements is difficult, where problems often arise during mixing, transferring to syringes, and subsequent injection. Via the use of premixed cements the risk of handling complications is reduced. However, for premixed cements to work in a clinical situation the setting time needs to be improved. The objective of this study is to investigate the influence of the addition of water on the properties of premixed cement. Monetite-forming premixed cements with small amounts of added water (less than 6.8 wt.%) were prepared and the influence on injectability, working time, setting time and mechanical strength was evaluated. The results showed that the addition of small amounts of water had significant influence on the properties of the premixed cement. With the addition of just 1.7 wt.% water, the force needed to extrude the cement from a syringe was reduced from 107 (± 15) N to 39 (± 9) N, the compression strength was almost doubled, and the setting time decreased from 29 (± 4) min to 19 (± 2) min, while the working time remained 5 to 6 h. This study demonstrates the importance of controlling the water content in premixed cement pastes and how water can be used to improve the properties of premixed cements.

► Addition of water decreases the extrusion force of an acidic pCPC from a syringe.
► Addition of water decreases the setting time for an acidic pCPC.
► Addition of water increases the compression strength for an acidic pCPC.
► A pCPC containing small amounts of water has a working time of several hours.
► MCPA can be used instead of MCPM in acidic pCPC to control the water content.