کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1429247 1509185 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of a novel supermagnetic iron oxide nanocomposite hydrogel based on graft copolymerization of poly((2-dimethylamino)ethyl methacrylate) onto salep for controlled release of drug
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Synthesis of a novel supermagnetic iron oxide nanocomposite hydrogel based on graft copolymerization of poly((2-dimethylamino)ethyl methacrylate) onto salep for controlled release of drug
چکیده انگلیسی


• We introduce a novel biocompatible magnetic iron oxide nanocomposite hydrogel for controlled drug release.
• We use a facile method to biocompatible magnetic iron oxide nanocomposite hydrogel.
• We prepare magnetic iron oxide nanocomposite hydrogel with high pH, temperature, and magnetic field-sensitivity.

In this research, a novel supermagnetic iron oxide nanocomposite hydrogel was prepared using simultaneous in situ formation of iron oxide nanoparticles (IONs) and three-dimensional cross-linked polymer networks based on graft copolymerization of poly((2-dimethylamino)ethyl methacrylate) (PDMA) onto salep (PDMA-g-salep). The prepared ION–PDMA-g-salep hydrogel was systematically characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy with energy dispersive X-ray analysis (SEM–EDAX), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). In addition, the ION–PDMA-g-salep hydrogel exhibits favorable swelling properties that are sensitive to temperature, pH, and external magnetic field (EMF). The drug release behavior of the prepared hydrogel under EMF, different temperatures and pHs was also studied for the evaluation of the release mechanism and determination of diffusion coefficients. Finally, the antibacterial activity and cytotoxicity studies of the prepared hydrogel were examined. These results suggested that the ION–PDMA-g-salep hydrogel could be a promising candidate for biological dressing applications.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 36, 1 March 2014, Pages 277–286
نویسندگان
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