کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1430037 987193 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and properties of poly(d,l-lactide) drug carrier with maghemite nanoparticles
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Synthesis and properties of poly(d,l-lactide) drug carrier with maghemite nanoparticles
چکیده انگلیسی

A magnetic polymeric carrier, composed of biodegradable poly(d,l-lactide) microspheres, maghemite nanoparticles and anti-cancer drug (paclitaxel) was successfully prepared in dichloromethane using high-speed homogenization. Maghemite nanoparticles were well dispersed in PLA matrix. The carrier was magnetically responsive and exhibited low cytotoxicity. Release of loaded paclitaxel was enhanced by applying an oscillating magnetic field. The thermal energy generated by maghemite nanoparticles due to magnetic hysteresis loss was very low and considered negligible in influencing the release behavior. Alternating movement of the nanoparticles, stimulated by magnetic force, resulting in deterioration of the mechanical properties of polymer matrix was likely to be the main reason for the enhancement in drug release.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 30, Issue 4, 10 May 2010, Pages 618–623
نویسندگان
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