کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1430250 987198 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications
چکیده انگلیسی

In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 29, Issue 8, 15 October 2009, Pages 2502–2507
نویسندگان
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