کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1430348 | 987201 | 2009 | 5 صفحه PDF | دانلود رایگان |
Alpha (α), beta (β) and gamma (γ) fatty ester cyclodextrins with C10 alkyl chains (CD-C10) on the secondary face were synthesized using an enzymatic pathway involving thermolysin as a biocatalyser. Depending on the formulation, these new cyclodextrin derivatives self-assembled and formed nanostructures presenting the ability to entrap diazepam, a lipophilic model drug. The loaded nanoparticles were tested for in vitro release of the drug molecule. Biphasic release profiles were observed with a pronounced delayed release in the case of γCD-C10 nanoparticles, associated to a low initial burst effect. These results are encouraging and may constitute the basis for designing novel multifunctional nanoscale systems made up with versatile cyclodextrin derivatives.
Journal: Materials Science and Engineering: C - Volume 29, Issue 2, 1 March 2009, Pages 458–462