کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1430917 | 987213 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Biomimetic patterning of polymer hydrogels with hydroxyapatite nanoparticles Biomimetic patterning of polymer hydrogels with hydroxyapatite nanoparticles](/preview/png/1430917.png)
We report here an in situ process to produce nano-composite polymer hydrogels having surfaces patterned with hydroxyapatite (HA) nanoparticles (100 nm). Poly (vinyl alcohol) (PVA) has been used as a hydrogel forming medium. A three step process, comprising precipitation of HA nanoparticles in presence of PVA molecules and freeze thawing of obtained PVA-HA emulsion, followed by critical point drying, has been devised to produce three dimensional nanocomposite hydrogels. Interaction of Ca2+ with oxygen atoms of PVA and the hydrogen bonding characteristic of the polymer have been exploited to have controlled size distribution of HA in a continuous and macroporous network of PVA. A systematic variation in the polymer concentration could be correlated with microstructural features of the hydrogel.
Journal: Materials Science and Engineering: C - Volume 29, Issue 4, 5 May 2009, Pages 1330–1333