کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
143261 163193 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The gene regulatory logic of transcription factor evolution
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
The gene regulatory logic of transcription factor evolution
چکیده انگلیسی

A growing debate in evolutionary and developmental biology concerns the relative contribution of cis-regulatory and protein (particularly transcription factor) changes to developmental evolution. Central to this argument are the perceived conservation of transcription factor functions and the modular architecture of cis-regulatory elements. In this paper, we review recent studies on transcription factor proteins that show that transcription factor genes undergo adaptive evolution and evolve novel functions that contribute to the evolution of development. Furthermore, we review experimental work that shows that transcription factor proteins are modular and can evolve with minimal pleiotropic effects. We conclude that changes in the function of proteins are likely directly contributing to developmental evolution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 23, Issue 7, July 2008, Pages 377–385
نویسندگان
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