کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
144485 438935 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation, characterization and dissolution behavior of artemisinin microparticles
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Preparation, characterization and dissolution behavior of artemisinin microparticles
چکیده انگلیسی

In the present study, a modified 4-fluid nozzle spray drier was used to prepare microparticles of a poorly water soluble drug, artemisinin with the aim of improving its solubility. We also investigated the effect of process variables on the physical properties and dissolution rate of spray dried artemisinin. A full factorial experimentally designed study was performed to investigate the following spray drying variables: inlet temperature and feed concentration. The artemisinin powder and spray dried artemisinin microparticles were characterized by scanning electron microscopy (SEM), differential scanning calorimetric (DSC), X-ray diffraction (XRD) and dissolution. SEM study suggested that the inlet temperature and feed concentration impacted on the particle size of the spray dried particles. The crystallinity of spray dried particles was slightly decreased with increasing inlet temperature and concentration. The dissolution of spray dried particles was markedly improved as compared to commercial artemisinin. A dissolution surface-response model was used to elucidate the significant and direct relationships between drug feed concentration and inlet temperature on one hand and dissolution on the other hand. The best dissolution was found to be 117.00 ± 5.15 μg/mL at the drug feed concentration of 10 g/L and inlet temperature of 140 °C.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Powder Technology - Volume 22, Issue 4, July 2011, Pages 458–463
نویسندگان
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