کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
144543 438938 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Powdered formulation of liquid oil terpenoid included in cyclodextrins for chemical stabilization and improved handling
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Powdered formulation of liquid oil terpenoid included in cyclodextrins for chemical stabilization and improved handling
چکیده انگلیسی

Teprenone (Tp) is a widely used pharmaceutically active ingredient in terpene anti-ulcer agents. We investigated Tp and cyclodextrin (CD) complexes for the objective of forming stable Tp powders. Tp was combined with each CD at a molar ratio of 1:2, kneaded together while adding an appropriate amount of water, then dried under reduced pressure and lightly milled into a powder to produce a kneaded mixture (KM). Powder X-ray diffraction of KM containing Tp and β- and γ-CD revealed new diffraction peaks. On infrared spectroscopy, the peak near 1718 cm−1 corresponding to the carbonyl group of Tp had shifted to around 1701 cm−1. Solid-state NMR spectroscopy showed signs of inhibited molecular mobility of Tp, which is liquid at room temperature, confirming that Tp had formed complexes with β- and γ-CD. Photostability analysis of Tp showed improved stability in the order of γ-CD > β-CD ≫ α-CD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Powder Technology - Volume 21, Issue 3, May 2010, Pages 326–330
نویسندگان
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