کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1460721 | 989609 | 2015 | 6 صفحه PDF | دانلود رایگان |
Magnetic nanoparticles for hyperthermic treatment of cancers have gained significant attention in recent years. In this work, biocompatible maghemite nanoparticles were synthesized by the oxidation of magnetite nanoparticles, using a coprecipitation method followed by heat treatment at different temperatures ranging from 200 to 300 °C for 3, 5 and 8 hours. The samples were analyzed by X-ray diffraction, vibrating sample magnetometry and transmission electron microscopy. The heating ability was evaluated under a magnetic field using a solid state induction heating equipment. Additionally, hemolysis test was performed. The obtained nanoferrites showed a particle size within the range of 10–11 nm and superparamagnetic behavior. The maghemite obtained at 250 °C for 5 hours was able to heat in concentrations of 13 mg/2 ml under a magnetic field (10.2 kAm−1 and frequency 362 kHz), increasing the temperature up to 49 °C. Hemolysis test, evaluated as release of hemoglobin, revealed that all the samples showed no hemolytic effects up to 3 mg/ml, indicating no damage of the red blood cell membranes. The results indicated that the maghemite nanoparticles obtained might be potential materials for cancer treatment by hyperthermia.
Journal: Ceramics International - Volume 41, Issue 1, Part A, January 2015, Pages 397–402