کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1464107 | 989656 | 2010 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Improvements in microstructural, mechanical, and biocompatibility properties of nano-sized hydroxyapatites doped with yttrium and fluoride Improvements in microstructural, mechanical, and biocompatibility properties of nano-sized hydroxyapatites doped with yttrium and fluoride](/preview/png/1464107.png)
Hydroxyapatite was doped with Y3+ (2.5, 5 and 7.5 mol%) and F− (2.5 mol%) ions (2.5YFHA, 5YFHA, 7.5YFHA, respectively) to compare its structural and mechanical properties and cellular response with pure-hydroxyapatite. No second phases were observed by X-ray diffraction spectra of 2.5YFHA. Doped hydroxyapatites had F− bonds in addition to OH− bonds. Hydroxyapatites sintered at 900 and 1100 °C were in nano-size. 7.5YFHA sintered at 1300 °C had the highest microhardness value. 2.5YFHA sintered at 1100 °C had the highest fracture toughness value. MTT viability assays showed high cell attachments on 2.5YFHA. Cell proliferation on 2.5YFHA and 5YFHA sintered at 1100 and 1300 °C was comparable with the control after 5-day culture. The highest ALP production and calcium deposition were observed on all hydroxyapatites sintered at 1100 °C. 2.5YFHA sintered at 1100 °C can be an alternative for hydroxyapatite in orthopedic applications.
Journal: Ceramics International - Volume 36, Issue 5, July 2010, Pages 1633–1643