کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1475065 991108 2012 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Calcium phosphate porous pellets as drug delivery systems: Effect of drug carrier composition on drug loading and in vitro release
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد سرامیک و کامپوزیت
پیش نمایش صفحه اول مقاله
Calcium phosphate porous pellets as drug delivery systems: Effect of drug carrier composition on drug loading and in vitro release
چکیده انگلیسی

Drug loaded porous calcium phosphate bone substitutes are studied for targeted drug delivery applications. In this study, porous hydroxyapatite and beta-tricalcium phosphate pellets were investigated as anti-inflammatory drug carriers and their ibuprofen adsorption and release properties were compared. While the adsorption equilibrium time of 1 h was obtained for both pellets, hydroxyapatite pellets showed a higher adsorption capacity than beta-tricalcium phosphate. The physico-chemical characterisations of loaded pellets confirmed an ibuprofen reversible physisorption on both hydroxyapatite and beta-tricalcium phosphate pellets. Moreover, higher adsorption capacity of hydroxyapatite was attributed to their physical differences. The in vitro ibuprofen release evaluation showed 100% release of ibuprofen from both hydroxyapatite and beta-tricalcium phosphate pellets which was found to be compatible with the obtained interactions between the pellets and ibuprofen.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the European Ceramic Society - Volume 32, Issue 11, August 2012, Pages 2679–2690
نویسندگان
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