Alendronate functionalized mesoporous hydroxyapatite nanoparticles for drug delivery

Mesoporous nanosized hydroxyapatite (HAP) functionalized by alendronate (ALN) was synthesized using cationic surfactant CTAB as template. The structural, morphological and textural properties were fully characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and N2 adsorption/desorption. Then the obtained materials were performed as drug delivery carriers using ibuprofen (IBU) as a model drug to investigate their drug storage/release properties in simulated body fluid (SBF). The materials showed relatively slower release rate compared with HAP due to the ionic interaction between NH3+ on the matrix and COO−belongs to IBU. The system provides a new concept for improving the drug loading or slowing down the release rate.

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► The synthesized mesoporous hydroxyapatite has nanostructure and bioactivity.
► The materials have high surface area and amino group.
► The materials show higher drug loading and slower release rate than pure HAP.