کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1490562 992328 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phase transfer of hydrophobic QDs for water-soluble and biocompatible nature through silanization
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد سرامیک و کامپوزیت
پیش نمایش صفحه اول مقاله
Phase transfer of hydrophobic QDs for water-soluble and biocompatible nature through silanization
چکیده انگلیسی

A novel method has been developed for creating water-soluble and biocompatible CdSe/ZnS quantum dots (QDs) with a small hydrodynamic diameter (less than 10 nm). The silanization of the QDs was carried out by using partially hydrolyzed tetraethyl orthosilicate (TEOS) to replace organic ammine or tri-n-octylphosphine oxide on the surface of the QDs. The partially hydrolyzed 3-mercaptopropyltrimethoxysilane attached to the hydrolyzed TEOS layer on the QDs prevented the QDs from agglomeration when the QDs were transferred into water. The functional SiO2-coated QDs were conjugated with immunoglobin G antibody by using biotin–streptavidin as linkers. The SiO2-coated QDs exhibited the same absorption and photoluminescence (PL) spectra as those of initial QDs in organic solvents. The SiO2-coated QDs preserved PL intensities, is colloidally stable over a wide pH range (pH 6–11). Because the mean diameter of amphiphilic polymer-coated QDs was almost 2 times of that of functional SiO2-coated QDs, the QD phase transfer by silanization is a well-established method for generating biocompatible QDs.

A facile and novel method has been developed for creating water-soluble and biocompatible CdSe/ZnS quantum dots with a small hydrodynamic diameter (less than 10 nm) via silanization.Figure optionsDownload as PowerPoint slideHighlights
► A facile and novel method has been developed for creating water-soluble and biocompatible CdSe/ZnS quantum dots (QDs) with a small hydrodynamic diameter (less than 10 nm).
► The control of ligand exchange plays an important role to retain high fluorescence quantum yields.
► The functional SiO2-coated QDs were conjugated with immunoglobin G antibody by using biotin–streptavidin as linkers.
► The QD phase transfer by silanization is a well-established method for generating biocompatible QDs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Research Bulletin - Volume 46, Issue 12, December 2011, Pages 2367–2372
نویسندگان
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