کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1491652 992356 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
pH-Controlled drug release from mesoporous silica tablets coated with hydroxypropyl methylcellulose phthalate
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد سرامیک و کامپوزیت
پیش نمایش صفحه اول مقاله
pH-Controlled drug release from mesoporous silica tablets coated with hydroxypropyl methylcellulose phthalate
چکیده انگلیسی

A simple pH-controlled drug release system was successfully prepared by coating pH-sensitive polymer hydroxypropyl methylcellulose phthalate (HPMCP) on drug-loaded mesoporous SBA-15 tablet. Using famotidine (Famo) as a model drug, the effects of coating times and drying temperature on drug release were studied in detail to optimize the drug release system. In simulated gastric fluid (SGF, pH 1.2), it took only 2 h for Famo to be completely released from mesoporous silica tablet without HPMCP coating. Also in SGF, with the increase of coating times and drying temperature, the release of Famo was greatly delayed by HPMCP coating. For the tablet with twice coating of HPMCP and dried at 80 °C, only 4.0 wt.% of Famo could be released within 4 h. However, in simulated intestinal fluid (SIF, pH 7.4), HPMCP coating did not show obvious effect on the release of Famo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Research Bulletin - Volume 44, Issue 3, 5 March 2009, Pages 606–612
نویسندگان
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