Biocompatible titania microtubes formed by nanoparticles and its application in the drug delivery of valproic acid

In this study we have successfully implanted an inorganic device consisting of titania microtubes in the brain of a wistar rat. Biocompatibility was established as shown by the fact that there were no perturbations on the surrounding tissue over a period of six months. An immunohistochemical study also showed that there were no alterations in the neighboring neurons over the six-month duration of the study.