کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1496919 992979 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural, optical and vibrational properties of sol-gel titania valproic acid reservoirs
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد سرامیک و کامپوزیت
پیش نمایش صفحه اول مقاله
Structural, optical and vibrational properties of sol-gel titania valproic acid reservoirs
چکیده انگلیسی
Organically modified sol-gel derived titania xerogels were prepared by co-gellation of titanium n-butoxide and 2-propylpentanoic acid (valproic acid) at room temperature. Materials with different content of valproic acid were obtained varying the concentration of the drug, during the mixing stage of the sol-gel processing with two concentrations 400 and 800 mg/g of titania. Resulting xerogels were characterized by infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and electron microscopy techniques. Analysis of infrared spectra provides information on the interaction between titania and the adsorbed valproic acid. XRD show an amorphous structure at room temperature. SEM micrographs revealed that the nanoparticles of the xerogels form heterogeneous plates, meanwhile a homogeneous nanostructure was observed by TEM. This study shows the optical and structural properties of the materials and the chemical stability of the encapsulated drug, and suggests that these sol-gel titania are promising carriers for controlled drug release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Optical Materials - Volume 29, Issue 1, October 2006, Pages 82-87
نویسندگان
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