Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells

► Plant polyphenol-loaded PCL nanofibers were fabricated by electrospinning. ► Nanofibers showed no burst release and controlled release of plant polyphenol. ► The released polyphenol can generate H2O2 that is the major cause of cytotoxicity of polyphenol. ► H2O2 generated by polyphenol was involved in apoptosis of cancer cells by activation of caspase-3.