Silica enhanced formation of hydroxyapatite nanocrystals in simulated body fluid (SBF) at 37 °C

► We report on fast formation of hexagonal nanocrystals of calcium hydroxyapatite (HA) in silica-containing simulated body fluid solution at 37 °C. ► Bioactivity and biodegradability of TCP precursor have been confirmed by the dissolution of TCP and formation of a bone like layer of new HA nanoparticles outside of the precursor after 24 h soaking in SBF solution. ► Successive nucleation and formation of tiny hexagonal HA nanoplates and nanorods have been confirmed by TEM results after 24 h soaking of TCP in silica-containing BSF solution.