کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1548672 997751 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced cell death by inosine pretreatment after photochemically induced cerebral ischemia in adult rats
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد مواد الکترونیکی، نوری و مغناطیسی
پیش نمایش صفحه اول مقاله
Reduced cell death by inosine pretreatment after photochemically induced cerebral ischemia in adult rats
چکیده انگلیسی

Protective effect of inosine against cell death after photochemically induced focal cerebral ischemia was investigated in adult rats. Intraperitoneal injection of inosine was started 24 h before operation and continued till the animals were sacrificed. The TUNEL method and Nissl staining were used to identify apoptosis and necrosis, respectively. TUNEL-positive cells were located in the transitional zone between the necrotic core and normal cortex. The mean maximum area of the necrotic cores and mean number of TUNEL-positive cells 24 h after operation were reduced significantly in the inosine-treated rats when compared with those in the saline-treated control animals. We suggest that inosine can significantly reduce both necrosis and apoptosis following cerebral ischemia induced by photothrombosis in adult rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Natural Science - Volume 18, Issue 12, 10 December 2008, Pages 1513–1518
نویسندگان
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