کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1556957 999220 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد شیمی مواد
پیش نمایش صفحه اول مقاله
Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells
چکیده انگلیسی
Biodegradation of magnesium (Mg) based metals in body fluid can lead to a strong alkalinity as well as an increase of Mg2+ concentration in its surrounding environment. In vitro cytotoxic effects of the extracts of pure Mg with and without micro arc oxidation (MAO) coating on osteosarcoma U2-OS cells, a kind of bone cancer cells, were preliminarily studied, independently considering the increase of either alkalinity or Mg2+ concentration. The results indicated that the high alkalinity, i.e., a great increase of pH value, caused by the degradations of Mg with and without MAO coating in the culture medium all showed strong cytotoxic effects on U2-OS cells. However, the increase of Mg2+ concentration had no such cytotoxic effect. This finding may provide an alternative way to cure bone cancers through creating a high alkalinity surrounding the cancer cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Materials Science & Technology - Volume 28, Issue 9, September 2012, Pages 769-772
نویسندگان
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