کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
156377 456930 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel organic–inorganic microhybrids containing anticancer agent doxifluridine and layered double hydroxides: Structure and controlled release properties
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
A novel organic–inorganic microhybrids containing anticancer agent doxifluridine and layered double hydroxides: Structure and controlled release properties
چکیده انگلیسی

For fully controlled drug release, it is important to completely understand the microstructure and nature of the layered double hydroxide that ultimately control drug release properties. In this study, a series of novel doxifluridine intercalated Mg–Al-layered double hydroxide (DFUR–LDH) microhybrids were fabricated via the reconstruction method. With increasing aging pH values from 7.2 to 9.5, two different LDH phases with varied basal spacings (d003) are formed. The DFUR–LDHr1.7p7.2 with d003 1.91 nm presents continuous worm-like morphology and possible bilayer interlayer arrangement, while DFUR–LDHr2.0p9.5 with d003 0.82 nm possesses discontinuous plate-like morphology and multi-sites interacted interlayer arrangement. Consequently, the in vitro release shows that the former has much longer release duration and a little faster initial release due to the weaker interaction between DFUR and LDH layers than that of the latter. The in vitro release data can be well described by the Bhaskar equation and modified Freundlich model, revealing that the release mechanism of DFUR from DFUR–LDH microhybrids is heterogeneous particle diffusion. Furthermore, the enteric polymer modified DFUR–LDHr1.7p7.2/L100 microspheres present no obvious release in pH 1.2 HCl solution, but continuous release of 79% in pH 6.8 and 7.4 PBS, suggesting a readily controlled release behavior upon the varied medium pH and potential application in colon specific drug delivery in cancer therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Science - Volume 65, Issue 12, 15 June 2010, Pages 3762–3771
نویسندگان
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