کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
156541 | 456937 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A new approach to high-shear mixer granulation using positron emission particle tracking
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
Positron emission particle tracking (PEPT) can provide quantitative information on particle motion in a mixer. For the first time, the present study clarifies the flow patterns of particles and granules during the process in which granules are formed in high-shear mixer granulation in three dimensions using PEPT. A number of different regions with size-dependent flows account for the variations in frequency and velocity of collisions between differently sized granules in the kernel when segregation occurs in the granulator. These findings offer a better understanding of the product properties and process attributes of high-shear mixer granulation, which will be of direct benefit as pharmaceutical and other products become more complex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Science - Volume 66, Issue 4, 15 February 2011, Pages 563–569
Journal: Chemical Engineering Science - Volume 66, Issue 4, 15 February 2011, Pages 563–569
نویسندگان
Yoshitoshi Saito, Xianfeng Fan, Andy Ingram, Jonathan Peter Kyle Seville,