کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1570261 | 1000568 | 2015 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Estimation of the spatial energy deposition in CA1 pyramidal neurons under exposure to 12C and 56Fe ion beams Estimation of the spatial energy deposition in CA1 pyramidal neurons under exposure to 12C and 56Fe ion beams](/preview/png/1570261.png)
The exposure to heavy charged particles represents a significant risk to the central nervous system. In experiments with rodents, the irradiation with heavy ions induces a prolonged deficit in hippocampus-dependent learning and memory. The exact nature of these violations remains mostly unclear. In this regard, the estimation of radiation effects at the level of single neurons is of our special interest. The present study demonstrates the results of comparative calculations that are performed to clarify the early physical events in single neurons under the exposure to accelerated 12C and 56Fe ions with different parameters. Using the Geant4-based Monte Carlo simulations, the radiation effects are considered in terms of energy and dose deposition. The spatial patterns of energy and dose depositions within a single neural cell are produced. As additional characteristics, the spectra of the specific energy and energy imparted are estimated. Our results show that the cell morphology is an important factor determining the accumulation of radiation dose in neurons under the exposure to heavy ions. The data obtained suggest a possibility of radiation damage to synapses that are considered to play an important role in radiation-induced violations of hippocampus-dependent learning and memory.
Journal: Journal of Radiation Research and Applied Sciences - Volume 8, Issue 4, October 2015, Pages 498–507