کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1589318 1001987 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Detection of erythrocytes in patient with elliptocytosis complicating ITP using atomic force microscopy
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد دانش مواد (عمومی)
پیش نمایش صفحه اول مقاله
Detection of erythrocytes in patient with elliptocytosis complicating ITP using atomic force microscopy
چکیده انگلیسی

The pathological changes of erythrocytes were detected at the nanometer scale, which was important for revealing the onset of diseases, early diagnosis, and effective therapies. Diseases may disturb the morphology and function of erythrocytes at molecular scale. There were dramatic surface deformations in topography of erythrocytes from a patient with elliptocytosis complicating idiopathic thrombocytopenic purpura (ITP). The overall shape and surface membrane of the healthy, pre- and post-therapeutic erythrocytes have been studied by high-resolution atomic force microscopy imaging. The results showed that we can detect healthy and pathological erythrocytes by the morphologic parameters of the length, width, ratio of length to width, peak, valley, valley-to-peak, surface fluctuation, and standard deviations of the erythrocytes. Therefore, the morphologic information of erythrocytes is very important indictor for diagnosing the healthy and disease, as well as evaluating therapeutic effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Micron - Volume 42, Issue 1, January 2011, Pages 42–46
نویسندگان
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