کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
160023 457056 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanofiltration membrane cascade for continuous solvent exchange
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Nanofiltration membrane cascade for continuous solvent exchange
چکیده انگلیسی

This paper proposes a continuous process for solvent exchange, a key unit operation for organic synthesis in pharmaceutical manufacturing. This process comprises a counter-current membrane cascade using organic solvent nanofiltration (OSN) membranes. The effect of process parameters, such as number of stages and flow rate ratio of replacing solvent to initial solvent, on solvent exchange performance are tested through simulations and experiments. Experimental results show 47.8%, 59.2%, and 75.3% solvent exchange for single-stage, two-stage and three-stage cascades, values which are close to the 50.0%, 66.6%, and 75.0% predicted by simulations. In general, the feasibility of OSN membrane cascades for continuous solvent exchange is demonstrated in this work.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Science - Volume 62, Issue 10, May 2007, Pages 2728–2736
نویسندگان
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