Controllable preparation and drug loading properties of core–shell microspheres Fe3O4@MOFs/GO

• Composite MOFs/GO was designed as the shell of microsphere.
• The structure and drug loading properties can be controlled.
• Different GO addition has different effect on magnetic microsphere.
• The optimal GO addition can help best structure and properties.

By exploring the layer-by-layer self-assembly method and the changes of content of graphene oxide (GO), controllable preparation of a new core–shell microsphere Fe3O4@MOFs/GO was achieved in this work. The prepared composite material was characterized by the XRD, FTIR, and TEM analysis. The application of Fe3O4@MOFs/GO as drug carrier for ibuprofen was studied. The results suggested that the properties of drug loading and release can be tuned by different layers and content of GO.