Regenerated cellulose/β-cyclodextrin scaffold prepared using ionic liquid

• RC/ β-CD tissue engineering scaffolds were prepared via ionic liquid.
• XRD shows the lower crystallinity of the scaffolds as compared to the pure RC.
• Scaffold exhibited interconnection and surface porosity.
• In vitro cytotoxicity test demonstrated that RC/β-CD scaffolds are cytocompatible.

Regenerated cellulose/β-cyclodextrin (RC/β-CD) tissue engineering scaffolds were fabricated by two particulate leaching techniques using environmental-friendly 1-butyl-3-methylimidazolium chloride (BMIMCl) ionic liquid. In one case, the pore inducing particles were water-soluble (edible salt) and in the other, they were water-insoluble poly (methyl methacrylate) (PMMA). The water-soluble particulate leaching and water-insoluble methods resulted in scaffolds with 70–75% and 91–93% porosity, respectively. X-ray diffraction revealed lower crystallinity of the RC/β-CD scaffolds as compared to pure RC. The RC/β-CD scaffolds prepared by water-insoluble leaching method showed the highest water uptake properties. In vitro cytotoxicity test demonstrated that RC/β-CD scaffolds are cytocompatible.

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