Intrinsically fluorescent hollow spheres based on organic–inorganic hybrid polyphosphazene material: Synthesis and application in drug release

• Intrinsically fluorescent hollow spheres based on organic–inorganic hybrid polyphosphazene material were fabricated.
• Abundant resveratrol groups were introduced into the polymeric shell.
• The submicrospheres are of favorable water dispersibility and sustained release.

Highly cross-linked organic–inorganic hybrid porous poly [(cyclotriphosphazene-co-resveratro)] spheres with hollow structure were prepared via precipitation polymerization of hexachlorocyclotriphosphazene and resveratrol. Poly [(cyclotriphosphazene-co-resveratro)] spheres mesoporous hollow spheres with resveratrol structures maintained intrinsical fluorescence and outstanding dispersability in both aqueous and organic media for their abundant functional groups. Besides, these cross-linked polyphosphazene spheres manifested high drug storage capacity and remarkable sustained release property. Moreover, the release rate of the drug from polyphosphazene microspheres was greatly dependent on pH value with resveratrol as a model molecule.