کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1644143 | 1517267 | 2014 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Chitosan/chondroitin sulfate multilayers as supports for calcium phosphate biomineralization Chitosan/chondroitin sulfate multilayers as supports for calcium phosphate biomineralization](/preview/png/1644143.png)
• Calcium phosphate precipitates were obtained in a nanostructured multilayer.
• The bioactive multilayer was composed of weak and natural polyelectrolytes.
• Films with more bilayers showed earlier calcification.
• Organic–inorganic composite biomaterials can be produced by this biomimetic approach.
We investigated the interaction of natural derived macromolecular multilayers with calcium and phosphate ions entirely processed using the layer-by-layer (LbL) technique. A nanostructured multilayer component, with 5 or 10 bilayers, was first produced using weak polyelectrolyte biopolymers, chitosan and chondroitin sulfate. This was followed by sequential passing of solutions containing Ca2+ and PO43−PO43− over the multilayers. QCM-D, SEM and EDX results conferred the formation of calcium phosphate (CaP) over the polyelectrolyte multilayers. Initiation of precipitation was observed earlier in the 10 bilayers coating than in the 5 bilayers one. These results indicate the potential of multilayers to trap ions, as a biomimetic approach that can be used to induce CaP precipitation. This could enable the preparation of more performant bioactive composite biomaterials for orthopedic applications, including in bone tissue engineering.
Journal: Materials Letters - Volume 121, 15 April 2014, Pages 62–65