Antimicrobial and biodegradable PLGA medical sutures with natural grapefruit seed extracts

This work demonstrates the development of novel antimicrobial and biodegradable suture coated by natural extract from grape fruit. The natural extract is loaded to PLGA suture and their optimum conditions are determined as a function of soaking time, loaded volume, and releasing time. Furthermore, the evaluation of antibacterial effect was achieved by Staphylococcus aureus and Escherchia DH5α with the used amounts and released time. The cell growth was calculated for several days through 2 months. The physicochemical properties of antimicrobial and biodegradable PLGA suture are demonstrated.

Novel antimicrobial and biodegradable PLGA sutures coated by a natural extract from grapefruit seed (GSE). The antimicrobial effect was evaluated against Staphylococcus aureus and Escherchia DH5α according to the used amounts and release time.Figure optionsDownload as PowerPoint slideHighlights
► Antimicrobial and biodegradable suture was prepared by natural grapefruit seed extracts.
► Antimicrobial evaluation was achieved against Staphylococcus aureus and Escherchia DH5α.
► The cell growth was calculated for a range of several days through 2 months.
► Antimicrobial mechanism was suggested by Real time RT-PCR with stress gene expression.