Drug delivery from titanium surface using biodegradable nanoparticle carriers

A simple and highly efficient method for drug delivery from titanium (Ti) surfaces using biodegradable nanoparticles was developed in this study. Resorbable blast media (RBM)-treated Ti surface was created by blasting with resorbable hydroxyapatite particles and used as a metal implant with a localized drug delivery structure. Human serum albumin (HSA) nanoparticles loaded with vancomycin (VAN) as a model drug were fabricated by a desolvation technique. The produced VAN-loaded HSA nanoparticles were pre-coated with positively charged poly(ethyleneimine) (PEI) molecules and then immobilized via electrical interaction on the Ti disc surfaces, which have a negative charge. The results indicated that the PEI-coated HSA nanoparticles loaded with VAN were successfully incorporated and well-dispersed on the Ti disc surfaces. The surface roughness of the Ti discs was not affected by immobilizing HSA nanoparticles and allowed complete localization of the drug delivery structure to the Ti disc surface. In addition, the results of the present study show that various therapeutic drugs that promote tissue responses can be efficiently incorporated onto Ti disc surfaces using biodegradable HSA nanoparticles.

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► A simple and highly efficient technique involving VAN-HSA-PEI nanoparticles was used to create an RBM-treated Ti disc surface with a controlled drug delivery system.
► The VAN-HSA-PEI nanoparticles with a positive charge were immobilized on the Ti disc surface with a negative charge via surface charge interactions.
► HSA nanoparticle-incorporated Ti disc surfaces can be used as an innovative platform for delivering therapeutic drugs.