In vitro performance of magnesium processed by different routes for bone regeneration applications

Magnesium processed by powder metallurgy (PM) and casting was investigated for potential use in bone regeneration applications. To reduce its corrosion rate, magnesium was surface-modified by a chemical conversion treatment in hydrofluoric acid (HF). In vitro behaviour was evaluated in terms of biodegradation and osteoblastic cell response. The metallurgical route used to produce magnesium has more significant consequences on biodegradation and biocompatibility than the effects of the surface coating. The coated magnesium processed by casting exhibits the best in vitro performance.

► Powder metallurgy magnesium and cast magnesium are studied for use as biomaterials.
► Biodegradation and biocompatibility are improved by a chemical conversion treatment.
► The metallurgical route exerts more significant effects than the surface coating.
► Coated cast magnesium exhibits the best in vitro performance.