Synthesis and characterization of polycationic chitosan-graft-poly (l-lysine)

A type of polysaccharide/polypeptide hydride material, chitosan derivatives with polypeptide side chains, was prepared via ring-opening polymerization of Nε-carbobenzyloxy-l-lysine NCA initiated by water-soluble chitosan and followed by removing the side-chain protective groups. The graft polymer was investigated through FTIR spectroscopy, proton nuclear magnetic resonance spectroscopy and X-ray diffraction to confirm the structure. Furthermore, the results of the atomic force microscopy (AFM) measurement indicated the chitosan-graft-poly (l-lysine) was a kind of extraordinary polycation.