Throughput maximization of particle radius measurements through balancing size versus current of the electron probe

► We seek the probe width that maximizes the throughput of particle radii measurements in HAADF STEM.► Bayesian experimental design uses the particle radii distributions as prior knowledge.► The optimal probe size is determined by the geometrical mean and the width of the radii distributions.► The particles' atomic number and the detector geometry are of only marginal importance.► We propose an adaptive approach where the probe width is changed mid-experiment.